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Martinos Centre for Biomedical Imaging, Department of Radiology, Harvard Healthcare University/Massachusetts Typical Medical center, [email protected], Challenge description and obligations: Medical evidences have substantially extended the practical scope of cerebellum from sensorimotor Management to a wide range of cognitions and feelings. Having said that, the underlying structural foundation to help the cognitive functions hasn't been set up in human, which hampers the development of focused therapies. The challenge aims to build a multi-scale imaging framework to elucidate the neuroarchitecture and connectivity maps with the human cerebellum. The framework pivots within the fusion of significant-resolution ex vivo MRI and automated serial-sectioning polarization sensitive optical coherence tomography (as-PSOCT) to enable tissue samples to generally be interrogated from single cells to your complete brain. 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